022: Ketogenesis Isn’t All About Carbs and Insulin (7/28/16)

Did you know that adding MCT oil to your pasta is more ketogenic than restricting your carbohydrates to ten percent of calories?

Many people think of carbohydrate and insulin as central to ketogenesis, but the direct biochemical event that initiates ketone formation is actually the oversupply of acetyl groups to the TCA cycle during conditions of oxaloacetate depletion.

While largely a biochemistry lesson, in this episode I also teach you the practical implications of this. There is more than one route to ketogenesis, and while they all produce ketones, they are fundamentally different in important ways.

Adding coconut, MCT oil, or exogenous ketones allows you to reap benefits of ketones without necessarily restricting carbohydrates and insulin, and that may be useful if you are also trying to reap some of the benefits of carbohydrate and insulin.

On the other hand, certain conditions that respond to ketogenic diets, for example refractory childhood epilepsy, need stronger degrees of ketogenesis than you can achieve simply by adding MCT oil to pasta.

Understanding the difference allows you to better make practical decisions about your diet that are most consistent with your priorities.

If you'd like to share the public version of this episode with non-Masterpass holders, you can find it here.
022: Ketogenesis Isn’t All About Carbs and Insulin (7/28/16)
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